The Renaissance started in Florence Italy because of several key factors of the Florence culture including:
All of these combined to make Florence, Italy the starting place of the Renaissance.

The Renaissance started in Florence, Italy because the city had the elements which helped the Renaissance begin and flourish:
During the Renaissance, there were advances in all the arts and sciences. In the 15th century, Florence was a wonderful place to be. There were many artists, architects, philosophers, and writers that had guilds whose members were influential in city politics. Florence was also known for its banking industry. So there was a lot of money and artists were influential in society.
Since the guilds made decisions about the city’s issues, money was spent on artistic and cultural endeavors. The Renaissance was the first time that artists were recognized for their talent and not just for craftsmanship. They came into their own during the Renaissance.
The Renaissance lasted for three centuries and brought about many changes in Europe. The Italian Renaissance was the beginning of the Renaissance, starting in Florence and soon spreading to the rest of Italy.
It is best know for its cultural achievements in literature, art, and architecture.
During the Renaissance, there was a return to ancient Greek and Roman ideals. Studying ancient texts led to development of zoology, botany, and astrology. Science and art went together, which is apparent in the work of da Vinci. His experiments and scientific method led the way for the modern science of today. Architecture also returned to the ancient ideals, with classic lines and symmetry.
This is obvious when looking at the arches, domes, columns, pilasters, and niches that were built. A great example of Renaissance architecture is St Peter’s Basilica.
The many excellent artists working in Italy at this time helped fuel the Renaissance in Italy.
Leonardo da Vinci lived from 1452 to 1519 and was one of the early figures of the Renaissance. He dabbled in much more than paint; he studied medicine, botany, math, geology, and warfare. He was a sculptor, inventor, musician, and architect as well as a painter. Notable works include: The Last Supper, Mona Lisa, and Vitruvian Man.
Michelangelo (1475 - 1564) was primarily a sculptor. He is best known for his work on the Sistine Chapel and his statue of David. Realism was extremely important to Renaissance artists, and the sculpture David had more energy, youthfulness, and emotion than sculptures of the past. It took him four years to paint the frescoes on the ceiling of the Sistine Chapel, because he had to paint while the plaster was wet.
Raphael was born in 1483 and died in 1520. He was the head architect of St. Peter’s Basilica. He also designed tapestries for the Sistine Chapel. He is well known for his frescoes named School of Athens.